Altered Expression of circulating Cdc42 in frontotemporal lobar degeneration

Claudia Saraceno, Marcella Catania, Anna Paterlini, Silvia Fostinelli, Miriam Ciani, Roberta Zanardini, Giuliano Binetti, Giuseppe Di Fede, Paola Caroppo, Luisa Benussi, Roberta Ghidoni, Silvia Bolognin

Research output: Contribution to journalArticle

Abstract

The term frontotemporal lobar degeneration (FTLD) defines a group of heterogeneous conditions histologically characterized by neuronal degeneration, inclusions of various proteins, and synaptic loss. However, the molecular mechanisms contributing to these alterations are still unknown. As the Rho-GTPase family member Cell division cycle 42 (Cdc42) plays a key role in the regulation of actin cytoskeleton dynamics and spine formation, we investigated whether Cdc42 protein levels were altered in the disease. Cdc42 was increased in the frontal cortex of FTLD patients compared to age-matched controls, but also in Alzheimer's disease (AD) patients included in the data-set. On the other hand, the pool of circulating Cdc42 in the plasma was altered in FTLD but not in AD patients. Interestingly, the stratification of the FTLD patients according to the different clinical variants showed a specific decrease of Cdc42 expression in the behavioral subgroup. This data support a role of Cdc42 in FTLD and specifically in the behavioral variant.

Original languageEnglish
Pages (from-to)1477-1483
Number of pages7
JournalJournal of Alzheimer's Disease
Volume61
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Cdc42
  • Frontotemporal dementia
  • Plasma
  • Rho-GTPases

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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  • Cite this

    Saraceno, C., Catania, M., Paterlini, A., Fostinelli, S., Ciani, M., Zanardini, R., Binetti, G., Di Fede, G., Caroppo, P., Benussi, L., Ghidoni, R., & Bolognin, S. (2018). Altered Expression of circulating Cdc42 in frontotemporal lobar degeneration. Journal of Alzheimer's Disease, 61(4), 1477-1483. https://doi.org/10.3233/JAD-170722