Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts

C. Pozzi, D. Peruccio, A. M. Dall'Omo, S. D'Alfonso, P. Savoia, M. G. Guerra, R. Miniero, M. Lecchi, L. Resegotti, P. Richiardi

Research output: Contribution to journalArticle

Abstract

HLA-A,B specificities were analysed on the neoplastic blasts of a panel of 69 lymphoblastic (ALL) and 50 non lymphoblastic (ANLL) acute leukaemias at onset using the standard lymphocytotoxicity technique. Analysis of the number of detected specificities per locus and, when possible, comparison of the results with those obtained on lymphocytes of the same patients during remission revealed many alterations in the expression of A,B specificities including extra specificities both at the HLA-A and -B loci mainly on lymphoblasts and missed specificities mainly at the HLA-B locus on myeloblasts. Lack of A,B antigens was complete in 6.2% of all tested samples (9% of ANLL) and selective for all the products of one locus in 16.8% of all tested samples (27.7% of ANLL). A decrease of class I molecules on the cell surface was evidenced with MoAb W6/32 on blasts missing detectable serological specificities.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalJournal of Immunogenetics
Volume17
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Pozzi, C., Peruccio, D., Dall'Omo, A. M., D'Alfonso, S., Savoia, P., Guerra, M. G., Miniero, R., Lecchi, M., Resegotti, L., & Richiardi, P. (1990). Altered expression of HLA-A,B specificities on acute lymphoid and myeloid leukaemia blasts. Journal of Immunogenetics, 17(3), 161-168.