Altered glutamate uptake in peripheral tissues from Down Syndrome patients

Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrarese

Research output: Contribution to journalArticle

Abstract

Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalNeuroscience Letters
Volume343
Issue number2
DOIs
Publication statusPublished - Jun 5 2003

Keywords

  • Down syndrome
  • Fibroblast
  • Glutamate uptake
  • Karyotype
  • Mitochondrial mutation
  • Platelet

ASJC Scopus subject areas

  • Neuroscience(all)

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