Altered glutamate uptake in peripheral tissues from Down Syndrome patients

Barbara Begni, Laura Brighina, Lorenzo Fumagalli, Simona Andreoni, Enrico Castelli, Claudia Francesconi, Roberto Del Bo, Nereo Bresolin, Carlo Ferrarese

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalNeuroscience Letters
Volume343
Issue number2
DOIs
Publication statusPublished - Jun 5 2003

Fingerprint

Down Syndrome
Glutamic Acid
Blood Platelets
Amyloid
Autopsy
Oxidative Stress
Fibroblasts
Brain

Keywords

  • Down syndrome
  • Fibroblast
  • Glutamate uptake
  • Karyotype
  • Mitochondrial mutation
  • Platelet

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Begni, B., Brighina, L., Fumagalli, L., Andreoni, S., Castelli, E., Francesconi, C., ... Ferrarese, C. (2003). Altered glutamate uptake in peripheral tissues from Down Syndrome patients. Neuroscience Letters, 343(2), 73-76. https://doi.org/10.1016/S0304-3940(03)00260-X

Altered glutamate uptake in peripheral tissues from Down Syndrome patients. / Begni, Barbara; Brighina, Laura; Fumagalli, Lorenzo; Andreoni, Simona; Castelli, Enrico; Francesconi, Claudia; Del Bo, Roberto; Bresolin, Nereo; Ferrarese, Carlo.

In: Neuroscience Letters, Vol. 343, No. 2, 05.06.2003, p. 73-76.

Research output: Contribution to journalArticle

Begni, B, Brighina, L, Fumagalli, L, Andreoni, S, Castelli, E, Francesconi, C, Del Bo, R, Bresolin, N & Ferrarese, C 2003, 'Altered glutamate uptake in peripheral tissues from Down Syndrome patients', Neuroscience Letters, vol. 343, no. 2, pp. 73-76. https://doi.org/10.1016/S0304-3940(03)00260-X
Begni, Barbara ; Brighina, Laura ; Fumagalli, Lorenzo ; Andreoni, Simona ; Castelli, Enrico ; Francesconi, Claudia ; Del Bo, Roberto ; Bresolin, Nereo ; Ferrarese, Carlo. / Altered glutamate uptake in peripheral tissues from Down Syndrome patients. In: Neuroscience Letters. 2003 ; Vol. 343, No. 2. pp. 73-76.
@article{6c0b32ae011b423bba17db3c3a67b22f,
title = "Altered glutamate uptake in peripheral tissues from Down Syndrome patients",
abstract = "Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P",
keywords = "Down syndrome, Fibroblast, Glutamate uptake, Karyotype, Mitochondrial mutation, Platelet",
author = "Barbara Begni and Laura Brighina and Lorenzo Fumagalli and Simona Andreoni and Enrico Castelli and Claudia Francesconi and {Del Bo}, Roberto and Nereo Bresolin and Carlo Ferrarese",
year = "2003",
month = "6",
day = "5",
doi = "10.1016/S0304-3940(03)00260-X",
language = "English",
volume = "343",
pages = "73--76",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Altered glutamate uptake in peripheral tissues from Down Syndrome patients

AU - Begni, Barbara

AU - Brighina, Laura

AU - Fumagalli, Lorenzo

AU - Andreoni, Simona

AU - Castelli, Enrico

AU - Francesconi, Claudia

AU - Del Bo, Roberto

AU - Bresolin, Nereo

AU - Ferrarese, Carlo

PY - 2003/6/5

Y1 - 2003/6/5

N2 - Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P

AB - Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P

KW - Down syndrome

KW - Fibroblast

KW - Glutamate uptake

KW - Karyotype

KW - Mitochondrial mutation

KW - Platelet

UR - http://www.scopus.com/inward/record.url?scp=0037718159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037718159&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(03)00260-X

DO - 10.1016/S0304-3940(03)00260-X

M3 - Article

C2 - 12759167

AN - SCOPUS:0037718159

VL - 343

SP - 73

EP - 76

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -