Altered inhibitory interaction among inferior frontal and motor cortex in l-dopa-induced dyskinesias

Viviana Ponzo, Silvia Picazio, Alberto Benussi, Francesco Di Lorenzo, Livia Brusa, Carlo Caltagirone, Giacomo Koch

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Levodopa-induced dyskinesias are associated with thalamo-cortical disinhibition and frontal area overactivation. Neuroimaging and transcranial magnetic stimulation studies have highlighted the involvement of the right inferior frontal cortex in levodopa-induced dyskinesias. Methods: Using transcranial magnetic stimulation, we tested connectivity between the inferior frontal and contralateral motor cortex in Parkinson's disease patients with and without levodopa-induced dyskinesias compared with age-matched controls. Furthermore, in dyskinetic patients, connectivity between the inferior frontal and contralateral motor cortex was assessed before and after a single session of continuous theta-burst stimulation applied over the inferior frontal cortex. Results: Dyskinetic patients showed abnormal facilitatory connectivity between the inferior frontal and motor cortex when compared with the nondyskinetic group. Continuous theta-burst stimulation over the inferior frontal cortex eliminated such facilitatory connectivity and decreased the levodopa-induced dyskinesias that was induced by a supramaximal dose of levodopa. Conclusion: In dyskinetic patients, a weaker inhibitory cortico-cortical interaction between the inferior frontal and contralateral motor cortex could be involved in levodopa-induced dyskinesias and restored by continuous theta-burst stimulation over the inferior frontal cortex.

Original languageEnglish
Pages (from-to)755-759
Number of pages5
JournalMovement Disorders
Volume31
Issue number5
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Inferior frontal cortex
  • Levodopa-induced dyskinesia
  • Parkinson's disease; connectivity
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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