Abstract
Several lines of evidence support the hypothesis of a toxic role played by wild type SOD1 (WT-SOD1) in the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). In this study we investigated both distribution and expression profile of WT-SOD1 in leukocytes from 19 SALS patients and 17 healthy individuals. Immunofluorescence experiments by confocal microscopy showed that SOD1 accumulates in the nuclear compartment in a group of SALS subjects. These results were also confirmed by western blot carried out on soluble nuclear and cytoplasmic fractions, with increased nuclear SOD1 level (p
| Original language | English |
|---|---|
| Article number | e75916 |
| Journal | PLoS One |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 14 2013 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis. / Cereda, Cristina; Leoni, Emanuela; Milani, Pamela; Pansarasa, Orietta; Mazzini, Giuliano; Guareschi, Stefania; Alvisi, Elena; Ghiroldi, Andrea; Diamanti, Luca; Bernuzzi, Stefano; Ceroni, Mauro; Cova, Emanuela.
In: PLoS One, Vol. 8, No. 10, e75916, 14.10.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis
AU - Cereda, Cristina
AU - Leoni, Emanuela
AU - Milani, Pamela
AU - Pansarasa, Orietta
AU - Mazzini, Giuliano
AU - Guareschi, Stefania
AU - Alvisi, Elena
AU - Ghiroldi, Andrea
AU - Diamanti, Luca
AU - Bernuzzi, Stefano
AU - Ceroni, Mauro
AU - Cova, Emanuela
PY - 2013/10/14
Y1 - 2013/10/14
N2 - Several lines of evidence support the hypothesis of a toxic role played by wild type SOD1 (WT-SOD1) in the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). In this study we investigated both distribution and expression profile of WT-SOD1 in leukocytes from 19 SALS patients and 17 healthy individuals. Immunofluorescence experiments by confocal microscopy showed that SOD1 accumulates in the nuclear compartment in a group of SALS subjects. These results were also confirmed by western blot carried out on soluble nuclear and cytoplasmic fractions, with increased nuclear SOD1 level (p
AB - Several lines of evidence support the hypothesis of a toxic role played by wild type SOD1 (WT-SOD1) in the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). In this study we investigated both distribution and expression profile of WT-SOD1 in leukocytes from 19 SALS patients and 17 healthy individuals. Immunofluorescence experiments by confocal microscopy showed that SOD1 accumulates in the nuclear compartment in a group of SALS subjects. These results were also confirmed by western blot carried out on soluble nuclear and cytoplasmic fractions, with increased nuclear SOD1 level (p
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UR - http://www.scopus.com/inward/citedby.url?scp=84885410476&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0075916
DO - 10.1371/journal.pone.0075916
M3 - Article
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e75916
ER -