Altered intraplatelet arachidonic acid metabolism during the acute state of unstable angina

Gian Gastone, Neri Serneri, Rosanna Abbate, Alida Panetta, Stefania Pinto, Stefania Favilla, Domenico Prisco, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Thromboxane A2 (TxA2) generation and 1-14C arachidonic acid (AA) metabolism by platelets (stimulated with thrombin) were studied in vitro in 16 patients with unstable angina both during the acute and chronic inactive phase of the angina. Eight patients with stable effort angina and 21 controls were also investigated. In acute unstable angina 1-14C AA metabolism was significantly increased through cyclooxygenase pathway resulting in a higher selective TxA2 generation than in stable effort angina and in controls (p

Original languageEnglish
Pages (from-to)303-316
Number of pages14
JournalThrombosis Research
Volume46
Issue number2
DOIs
Publication statusPublished - Apr 15 1987

Keywords

  • 12 -hydroxy-eicosatetraenoic acid
  • arachidonic acid
  • ischemic heart disease
  • prostaglandins
  • thromboxane A2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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