Altered levels of nerve growth factor in the thymus of subjects with myasthenia gravis

Barbara Stampachiacchiere, Tsvetana Marinova, Kamelia Velikova, Stanislav Philipov, Ivan S. Stankulov, George N. Chaldakov, Marco Fiore, Luigi Aloe

Research output: Contribution to journalArticle

Abstract

We have previously reported that nerve growth factor (NGF), a polypeptide known for its neurotrophic activities, is also involved in the differentiation and survival of immune cells, and that NGF and its high-affinity receptor are present in the thymus. We here demonstrate that the thymus of humans affected by myasthenia gravis (MG) contains significant concentrations of NGF. These observations support our hypothesis of a role for NGF in the thymus and suggest that the changes observed in the thymus of subject with MG may have functional significance.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalJournal of Neuroimmunology
Volume146
Issue number1-2
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Epithelial cells
  • Mast cells
  • Myasthenia gravis
  • NGF
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Stampachiacchiere, B., Marinova, T., Velikova, K., Philipov, S., Stankulov, I. S., Chaldakov, G. N., Fiore, M., & Aloe, L. (2004). Altered levels of nerve growth factor in the thymus of subjects with myasthenia gravis. Journal of Neuroimmunology, 146(1-2), 199-202. https://doi.org/10.1016/j.jneuroim.2003.10.048