Altered muscle energy metabolism in post-absorptive patients with chronic renal failure

Ornella Pastoris, Roberto Aquilani, Paola Foppa, Giacomo Bovio, Siro Segagni, Paola Baiardi, Mariana Catapano, Massimo Maccario, Alessandro Salvadeo, Maurizia Dossena

Research output: Contribution to journalArticlepeer-review

Abstract

Skeletal muscle biopsies were performed on 12 healthy sedentary subjects and on 22 non-dyalized chronic renal failure patients (CRF) on a free diet and after overnight fasting. Parathormone, glucagon and insulin were determined at the same time of biopsies. CRF patients showed significantly low ATP and creatine phosphate levels. Regarding enzyme activities, a high hexokinase V(max) was found, while the pyruvate kinase activity was lower than in the control group. For the tricarboxylic acid cycle, citrate synthase, succinate dehydrogenase and malate dehydrogenase activities were higher; total NADH cytochrome c reductase activity was also high, while cytochrome oxidase activity was slightly lower. Both alanine aminotransferase and aspartate aminotransferase activities were considerably high in comparison with the control group. In conclusion, our study revealed a hypermetabolic TCA cycle, but impaired oxidative phosphorylation, which partly explained the reduced ATP concentration. Excessive protein intake and hormonal derangements may play a role in these metabolic changes.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalScandinavian Journal of Urology and Nephrology
Volume31
Issue number3
Publication statusPublished - 1997

Keywords

  • Energy mediators
  • Enzyme activities
  • Skeletal muscle
  • Uremia

ASJC Scopus subject areas

  • Nephrology
  • Urology

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