Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis

Alessandra Micera, Alessandro Lambiase, Paolo Rama, Luigi Aloe

Research output: Contribution to journalArticle

Abstract

In this study we measured with a highly sensitive two-site immunoenzymatic assay the levels of nerve growth factor (NGF) in human optic nerve affected by multiple sclerosis (MS). The result of this study showed an elevated increase of NGF in the MS optic nerves, as compared to the level of NGF found in the optic nerves non-affected by this demyelinating disorder. Moreover, the results showed that the optic nerves also expressed trkA NGF receptor and NGFmRNA, most likely by oligodendrocytes, implying that NGF is locally produced and suggesting that the presence of NGF might be regulated by an autocrine mechanism. These and other ongoing studies on animal models indicate that altered NGF levels are among one of the early symptoms of these demyelinating diseases. The physiopathological role of NGF in the optic nerve during demyelinating disorders remains however to be defined.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalMultiple Sclerosis Journal
Volume5
Issue number6
Publication statusPublished - Dec 1999

Keywords

  • Demyelinating disorders
  • Multiple sclerosis
  • NGF
  • NGFmRNA
  • Oligodendrocytes
  • Optic nerve
  • trkA

ASJC Scopus subject areas

  • Clinical Neurology

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