Altered proportion of Tμ- and Tγ-cell sub-populations in patients with Hodgkin's disease

S. Romagnani, E. Maggi, R. Biagiotti, M. G. Giudizi, A. Amadori, M. Ricci

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of peripheral blood lymphocytes from patients with Hodgkin's disease (HD) to form rosettes with ox red blood cells (ORBC) sensitized by anti-ORBC purified rabbit IgM and IgG was investigated. The mean percentage of cells capable of forming rosettes with ORBC coated with IgM (EA(IGM)-RFC) in the peripheral blood of either untreated or X-ray-treated patients with HD was significantly lower than of normal individuals. In the same goups of patients with HD the mean percentage of T lymphocytes equipped with receptor for IgG (Tγ lymphocytes), evaluated by a mixed fluorescent rosette assay, was significantly higher than in normal controls. These data suggest that the altered proportion between Tμ- and Tγ-cell subpopulations in patients with HD probably represents a disease-related phenomenon.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalScandinavian Journal of Immunology
Volume7
Issue number6
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Immunology

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