Altered protein kinase activities of lymphoid cells transformed by Abelson and Moloney leukemia viruses

Anna Maria Brunati, Daniela Saggioro, Luigi Chieco-Bianci, Lorenzo A. Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Five different types of protein kinase acivities have been evaluated in cell lines from murine lymphomas induced by Abelson leukemia virus (A-MuLV), whose oncogene codes for a tyrosine protein kinase. Such activities were compared with those of normal cells and of cells transformed by Moloney leukamia virus (M-MuLV), lacking oncogene sequences in its genome. While cAMP-dependent protein kinase and casein kinase-1 do not undergo significant changes, casein kinase-2 rises in both A-MuLV and M-MuLV infected lymphocytes, becoming largely associated with the particulate fraction of transformed cells. Protein kinase-C on the other hand is unchanged in M-MuLV transformed cells but it undergoes a 2-3-fold increment in both soluble and particulate fractions of A-MuLV transformed lymphocytes, which also display high tyrosine protein kinase activity.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalFEBS Letters
Volume206
Issue number1
DOIs
Publication statusPublished - Sep 29 1986

Keywords

  • (Thymocyte)
  • Abelson leukemia virus
  • Casein kinase 2 Tyrosine protein kinase
  • Moloney leukemia virus
  • Protein kinase C

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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