Altered release of cytochrome P450 metabolites of arachidonic acid in renovascular disease

Pietro Minuz, Houli Jiang, Cristiano Fava, Lucia Turolo, Stefania Tacconelli, Marco Ricci, Paola Patrignani, Alberto Morganti, Alessandro Lechi, John C. McGiff

Research output: Contribution to journalArticle

Abstract

The aim of the present cross-sectional study was to investigate whether activation of the renin-angiotensin system in renovascular disease affects the cytochrome P450 ω/ω-1 hydroxylase (20-hydroxyeicosatetraenoic acid [20-HETE]) and epoxygenase (epoxyeicosatrienoic acids [EETs]) pathways of arachidonic acid metabolism in vivo, each of which interacts with angiotensin II. Plasma concentration and urinary excretion of 20-HETE and EETs and their metabolites, dihydroxyeicosatrienoic acids, were measured in urine and plasma by mass spectrometry in 10 subjects with renovascular disease, 10 with essential hypertension, and 10 healthy normotensive subjects (control subjects), pair-matched for gender and age. Vascular and renal function were evaluated in all of the subjects. Plasma 20-HETE was highest in subjects with renovascular disease (median: 1.20 ng/mL; range: 0.42 to 1.92 ng/mL) compared with subjects with essential hypertension (median: 0.90 ng/mL; range: 0.40 to 2.17 ng/mL) and control subjects (median: 0.45 ng/mL; range: 0.14 to 1.70 ng/mL; P

Original languageEnglish
Pages (from-to)1379-1385
Number of pages7
JournalHypertension
Volume51
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • 20-HETE
  • Angiotensin II
  • DHETs
  • EETs
  • Eicosanoids
  • Hypertension
  • Renal artery stenosis

ASJC Scopus subject areas

  • Internal Medicine

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    Minuz, P., Jiang, H., Fava, C., Turolo, L., Tacconelli, S., Ricci, M., Patrignani, P., Morganti, A., Lechi, A., & McGiff, J. C. (2008). Altered release of cytochrome P450 metabolites of arachidonic acid in renovascular disease. Hypertension, 51(5), 1379-1385. https://doi.org/10.1161/HYPERTENSIONAHA.107.105395