Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria)

Roberto Gherzi, Carlo Bellini, Eugenio Bonioli

Research output: Contribution to journalArticlepeer-review

Abstract

Cell senescence produces changes in the expression of specific genes, suggesting that senescent cells express an altered pattern of transcription factors. Here we describe how the DNA binding activity of the activator protein 1 (AP-1) complex is altered in the fibroblasts of a geroderma osteodysplastica patient in response to extracellular stimuli.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalMechanisms of Ageing and Development
Volume100
Issue number2
DOIs
Publication statusPublished - Jan 30 1998

Keywords

  • AP-1
  • Binding activity
  • Fibroblasts
  • GO17

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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