Altered restriction pattern of the putative DNA binding domain of estrogen receptor or related genes in primary human meningiomas

A. Vacca, V. M. Fazio, O. Gandini, P. Oppido, R. Delfini, L. Frati, A. Gulino

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed by restriction mapping the genomic organization of the estrogen receptor gene in several primary human brain tumors in order to investigate the possible relationships between the development of these tumors and gonadal steroid hormones. In 5 out of 23 meningiomas the Eco RI restriction of genomic DNAs revealed 6 invariant normal fragments of 6.5, 4.8, 3.8, 3.1, 2.7 and 1.7 kb, plus 2 additional variant fragments of either 8.6 or 2.5 kb. More detailed analysis showed that these variant bands hybridized with a probe specific for the middle region of the estrogen receptor cDNA, coding for the DNA-binding domain of the receptor. This abnormal restriction pattern was found only in these meningiomas and not in other brain tumors or DNAs obtained from peripheral blood lymphocytes.

Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalInternational Journal of Cancer
Volume43
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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