Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks

Eleonora Vannini, Laura Restani, Marta Pietrasanta, Alessandro Panarese, Alberto Mazzoni, Ornella Rossetto, Silvia Middei, Silvestro Micera, Matteo Caleo

Research output: Contribution to journalArticlepeer-review

Abstract

Epilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined alterations in sensory processing and the underlying biochemical and neuroanatomical changes in tetanus neurotoxin (TeNT)-induced focal epilepsy in mouse visual cortex. We documented persistent epileptiform electrographic discharges and upregulation of GABAergic markers at the completion of TeNT effects. We also found a significant remodeling of the dendritic arbors of pyramidal neurons, with increased dendritic length and branching, and overall reduction in spine density but significant preservation of mushroom, mature spines. Functionally, spontaneous neuronal discharge was increased, visual responses were less reliable, and electrophysiological and behavioural visual acuity was consistently impaired in TeNT-injected mice. These data demonstrate robust, long-term remodeling of both inhibitory and excitatory circuitry associated with specific disturbances of network function in neocortical epilepsy.

Original languageEnglish
Pages (from-to)2919-2936
Number of pages18
JournalBrain Structure and Function
Volume221
Issue number6
DOIs
Publication statusPublished - Jul 1 2016
Externally publishedYes

Keywords

  • Dendritic spines
  • Epilepsy
  • Spontaneous activity
  • Tetanus neurotoxin
  • Visual acuity
  • Visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology

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