Altered structure of small cerebral arteries in patients with essential hypertension

Damiano Rizzoni, Carolina De Ciuceis, Enzo Porteri, Silvia Paiardi, Gianluca E M Boari, Pietro Mortini, Claudio Cornali, Marco Cenzato, Luigi F. Rodella, Elisa Borsani, Nicola Rizzardi, Caterina Platto, Rita Rezzani, Enrico Agabiti Rosei

Research output: Contribution to journalArticle

Abstract

Objective Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased media-to-lumen ratio of subcutaneous small resistance arteries has been demonstrated to predict the development of cardiocerebrovascular events in hypertensive patients. Alterations in the structure of small cerebral arteries have been demonstrated in animal models of experimental or genetic hypertension. However, no evaluation with reliable techniques has ever been performed in humans. Design and methods Twenty-eight participants were included in the present study: they were 13 hypertensive patients and 15 normotensive individuals. All participants underwent a neurosurgical intervention for benign or malign tumors. A small portion of morphologically normal cerebral tissue was excised from surgical samples and examined. Cerebral small resistance arteries (relaxed diameter around 200 μm) were dissected and mounted on an isometric and isobaric myograph, and the tunica media to internal lumen ratio was measured. In addition, cerebral cortical microvessel density (MVD) was also evaluated. The tissue was sectioned and stained for CD31, and MVD was measured with an automated image analyzer (percentage of area stained). Blood pressure values were evaluated, before surgical intervention, by standard sphygmomanometry. Results M/L was significantly greater and MVD significantly lower in hypertensive patients than that in normotensive individuals. No difference between groups in collagen content or mechanical properties of cerebral small arteries was observed. Conclusion Our results indicate that structural alterations of small cerebral vessels are present in hypertensive patients compared with normotensive individuals, similar to those previously observed in subcutaneous small arteries.

Original languageEnglish
Pages (from-to)838-845
Number of pages8
JournalJournal of Hypertension
Volume27
Issue number4
DOIs
Publication statusPublished - Apr 2009

    Fingerprint

Keywords

  • Brain
  • Capillaries
  • Cerebral small arteries
  • Hypertension
  • Microcirculation
  • Microvascular rarefaction
  • Small resistance arteries
  • Small vessels

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Rizzoni, D., De Ciuceis, C., Porteri, E., Paiardi, S., Boari, G. E. M., Mortini, P., Cornali, C., Cenzato, M., Rodella, L. F., Borsani, E., Rizzardi, N., Platto, C., Rezzani, R., & Rosei, E. A. (2009). Altered structure of small cerebral arteries in patients with essential hypertension. Journal of Hypertension, 27(4), 838-845. https://doi.org/10.1097/HJH.0b013e32832401ea