Alternating combination chemotherapy of advanced soft tissue sarcomas in adults

M. Lopez, L. Di Lauro, P. Papaldo, C. F. Perno

Research output: Contribution to journalArticlepeer-review


The possibility of improving treatment results using an alternating combination chemotherapy was explored in 40 evaluable patients with advanced soft tissue sarcomas. Treatment regimen consisted of adriamycin and DTIC alternating with vincristine, actinomycin D, and cyclophosphamide. Four patients achieved a complete response and eight achieved a partial response, with an overall response rate of 30%. The median survival time was 28 months for responders compared with 7 months for nonresponders (p = 0.001). Toxicity was predominantly limited to nausea, vomiting, and myelosuppression. Although this alternating regimen failed to improve response rates over other combinations, survival times observed in the present study should provide impetus to evaluate further the concept of sequential noncross-resistant combinations.

Original languageEnglish
Pages (from-to)539-542
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number5
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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