Alternating drug combinations in the treatment of advanced Hodgkin's disease

A. Santoro, G. Bonadonna, V. Bonfante, P. Valagussa

Research output: Contribution to journalArticlepeer-review


Of 75 consecutive patients with Stage IV Hodgkin's disease, we assigned 38 to receive MOPP alone (mechlorethamine, vincristine, procarbazine, and prednisone) and 37 to receive MOPP alternating monthly with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) - a combination of drugs not cross-resistant with MOPP. Complete remission was documented in 71 per cent of the patients receiving MOPP alone and in 92 per cent of those receiving the alternating regimen (P = 0.02). At five years, there was no progression of disease in 37 per cent of the MOPP group and in 70 per cent of the MOPP-plus-ABVD group (P

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalNew England Journal of Medicine
Issue number13
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Alternating drug combinations in the treatment of advanced Hodgkin's disease'. Together they form a unique fingerprint.

Cite this