Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity

B. Scott Davidson, Francesco Izzo, Judy L. Chase, Ronelle A. DuBrow, Yehuda Patt, David C. Hohn, Steven A. Curley

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalAmerican Journal of Surgery
Volume172
Issue number3
DOIs
Publication statusPublished - Sep 1996

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ASJC Scopus subject areas

  • Surgery

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