Abstract
BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P
| Original language | English |
|---|---|
| Pages (from-to) | 244-247 |
| Number of pages | 4 |
| Journal | American Journal of Surgery |
| Volume | 172 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1996 |
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ASJC Scopus subject areas
- Surgery
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Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity. / Davidson, B. Scott; Izzo, Francesco; Chase, Judy L.; DuBrow, Ronelle A.; Patt, Yehuda; Hohn, David C.; Curley, Steven A.
In: American Journal of Surgery, Vol. 172, No. 3, 09.1996, p. 244-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity
AU - Davidson, B. Scott
AU - Izzo, Francesco
AU - Chase, Judy L.
AU - DuBrow, Ronelle A.
AU - Patt, Yehuda
AU - Hohn, David C.
AU - Curley, Steven A.
PY - 1996/9
Y1 - 1996/9
N2 - BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P
AB - BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P
UR - http://www.scopus.com/inward/record.url?scp=0030249457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030249457&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(96)00159-6
DO - 10.1016/S0002-9610(96)00159-6
M3 - Article
C2 - 8862076
AN - SCOPUS:0030249457
VL - 172
SP - 244
EP - 247
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 3
ER -