Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity

B. Scott Davidson; Francesco Izzo; Judy L. Chase; Ronelle A. DuBrow; Yehuda Patt; David C. Hohn; Steven A. Curley

doi:10.1016/S0002-9610(96)00159-6

Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity

B. Scott Davidson, Francesco Izzo, Judy L. Chase, Ronelle A. DuBrow, Yehuda Patt, David C. Hohn, Steven A. Curley

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	American Journal of Surgery
Volume	172
Issue number	3
DOIs	https://doi.org/10.1016/S0002-9610(96)00159-6
Publication status	Published - Sep 1996

ASJC Scopus subject areas

Surgery

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10.1016/S0002-9610(96)00159-6

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title = "Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity",

abstract = "BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P ",

author = "Davidson, {B. Scott} and Francesco Izzo and Chase, {Judy L.} and DuBrow, {Ronelle A.} and Yehuda Patt and Hohn, {David C.} and Curley, {Steven A.}",

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T1 - Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity

AU - Davidson, B. Scott

AU - Izzo, Francesco

AU - Chase, Judy L.

AU - DuBrow, Ronelle A.

AU - Patt, Yehuda

AU - Hohn, David C.

AU - Curley, Steven A.

PY - 1996/9

Y1 - 1996/9

N2 - BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P

AB - BACKGROUND: The goals of this study of a hepatic arterial infusion (HAI) regimen of alternating floxuridine and 5-fluorouracil were to evaluate the treatment-related toxic effects, the antitumor response rate, and patient survival. METHODS: Fifty-seven consecutive patients were treated with implanted HAI pumps and received a regimen of alternating floxuridine (0.1 mg/kg/day continuous HAI for 7 days) followed by a weekly HAI pump bolus of 5-fluorouracil (15 mg/kg for 3 weeks). Any changes in treatment plan because of toxicity, antitumor response, and survival were recorded. RESULTS: Thirty- one (54.4%) patients responded to this HAI regimen; 14 (24.5%) patients had stable disease, and 12 (21.1%) progressed during treatment. Responders or patients with stable disease had a significantly (P

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Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity

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