Alternative donors hematopoietic stem cells transplantation for adults with acute myeloid leukemia: Umbilical cord blood or haploidentical donors?

Annalisa Ruggeri, Fabio Ciceri, Eliane Gluckman, Myriam Labopin, Vanderson Rocha

Research output: Contribution to journalArticlepeer-review

Abstract

Use of allogeneic transplantation for patients with acute myeloid leukemia (AML) depends mainly on the risk of the disease, and HLA matched donor availability. In patients with high-risk leukemia, in the absence of a HLA (human leukocyte antigen) matched donor, alternative donors such as unrelated umbilical cord blood (UCB) or haploidentical donor (haplo) have been currently used. Both strategies have important advantages such as shorter time to transplant, which is particularly relevant to patients requiring urgent transplantation, and tolerance of HLA mismatched graft that make possible that a donor can be found for virtually all patients. However, in spite of higher incidence of graft failure in UCB transplatation recipients and higher relapse incidence after haplo transplants, final outcomes seem to be comparable with HLA matched unrelated hematopoietic stem cell transplantation (bone marrow or peripheral blood). Therefore, the complexity of choosing the best alternative donor will depend on urgency of the transplantation, status and risk of the disease, donor criteria and center experience. Here we review the current status of UCBT and haplo transplants to treat adults with high-risk acute myeloid leukemia and we discuss the main issues associated with the use of both hematopoietic stem cell transplant approaches.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalBest Practice and Research: Clinical Haematology
Volume23
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords

  • acute myeloid leukemial
  • adult
  • cord blood transplantation
  • haploidentical transplantation

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Alternative donors hematopoietic stem cells transplantation for adults with acute myeloid leukemia: Umbilical cord blood or haploidentical donors?'. Together they form a unique fingerprint.

Cite this