Alternative transplantation sites for pancreatic islet grafts

Elisa Cantarelli, Lorenzo Piemonti

Research output: Contribution to journalArticle

Abstract

The liver is the current site of choice for pancreatic islet transplantation, even though it is far from being an ideal site because of immunologic, anatomic, and physiologic factors leading to a significant early graft loss. A huge amount of alternative sites have been used for islet transplantation in experimental animal models to provide improved engraftment and long-term survival minimizing surgical complications. The pancreas, gastric submucosa, genitourinary tract, muscle, omentum, bone marrow, kidney capsule, peritoneum, anterior eye chamber, testis, and thymus have been explored. Site-specific differences exist in term of islet engraftment, but few alternative sites have potential clinical translation and generally the evidence of a post-transplant islet function better than that reached after intraportal infusion is still lacking. This review discusses site-specific benefits and drawbacks taking into account immunologic, metabolic, and technical aspects to identify the ideal microenvironment for islet function and survival.

Original languageEnglish
Pages (from-to)364-374
Number of pages11
JournalCurrent Diabetes Reports
Volume11
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Alternative site
  • Early challenges
  • Engraftment
  • Extravascular sites
  • Immunoprivileged sites
  • Intravascular sites
  • Islet transplantation
  • Late challenges
  • Microenvironment
  • Pancreatic islet graft

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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