Alternatives for the treatment of local advanced disease: Electrochemotherapy, limb perfusion, limb infusion, intralesional IL2.What is the role?

Alessandro Testori, Antonio Intelisano, Francesco Verrecchia, Claudia Menicanti, Giulio Tosti, Elisa Grassi, Chiara Pari, Elisabetta Pennacchioli

Research output: Contribution to journalArticlepeer-review

Abstract

Nowadays, melanoma is one of the most common fatal malignancy of young adults. Incidence is increasing, but mortality rates from melanoma have remained stable. In-transit metastases from extremity or trunk melanoma are subcutaneous or cutaneous deposits of melanoma distant from the primary site, but not reaching the draining nodal basin. According to American Joint Committee on Cancer classification of stages based on Tumor, Node, Metastases classification stages IIIb and IIIc are considered local advanced disease and survival outcomes is quite poor, with 5-year survival rates of 24-54%. Loco-regional recurrence is an important risk factor for distant metastatic disease, either synchrone or metachrone. Therapy for this pattern of recurrence is limited and options vary based on the volume and site of disease. Definitive surgical resection remains the preferred therapeutic approach. However, when surgery cannot be performed with a reasonable cosmetic and functional outcome, other options must be utilized. Treatment options are classified as local, regional, or systemic. The choice of therapy depends on the number of lesions, their anatomic location, whether or not they are dermal or subcutaneous, the size, and the presence or absence of extra-regional disease

Original languageEnglish
Pages (from-to)443-451
Number of pages9
JournalDermatologic Therapy
Volume25
Issue number5
DOIs
Publication statusPublished - Sep 2012

Keywords

  • in-transit metastasis
  • loco-regional treatment
  • melanoma

ASJC Scopus subject areas

  • Dermatology

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