To assess whether parathyroid hormone (PTH) has any effect on bone aluminium (Al) accumulation, we evaluated the relationship between bone quantitative histomorphometry and bone Al content in 25 dialysis patients with clinical features of secondary hyperparathyroidism. By means of bone biopsy, patients were classified as showing predominant hyperparathyroidism in 17 cases and mixed lesions in 8. The Al burden was low, judging from the dialysate Al and the oral Al assumption. Bone Al content and serum Al levels were higher than normal in both groups, particularly so in the patients with predominant hyperparathyroidism. Significant positive correlations were found between bone indexes of hyperparathyroidism and bone Al content. Moreover, bone and serum Al concentrations were directly related. Aluminium staining appeared faintly positive only in a minority of bone samples, and was mainly localized at the neutral bone surfaces. We conclude that in dialysis osteodystrophies with features of secondary hyperparathyroidism and in a clinical setting characterized by low-grade Al burden, PTH may favour Al accumulation into the bone.
|Number of pages||6|
|Journal||Mineral and Electrolyte Metabolism|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism