Alveolar Adenoma of the Lung: A Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Case

Alberto Cavazza, Massimiliano Paci, Loredana De Marco, Guido Leporati, Giuliana Sartori, Nazzarena Bigiani, Giulio Rossi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We describe an alveolar adenoma of the lung with 3 previously unreported findings, which expand both the clinical and the morphologic spectrum of this rare tumor: presentation as a cystic nodule, foci of mature adipocytes, and S-100 positivity of the mesenchymal cells. Furthermore, using a laser capture microdissection technique under microscope visualization, we analyzed multiple chromosomal loci in both the epithelial and mesenchymal components of the lesion, showing microsatellite alterations and loss of heterozygosity in the former but not in the latter.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 2004

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Laser Capture Microdissection
Loss of Heterozygosity
Adipocytes
Adenoma
Microsatellite Repeats
Lung
Neoplasms

Keywords

  • Adipocytes
  • Alveolar adenoma
  • Cyst
  • LOH
  • Lung
  • Microsatellites

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Alveolar Adenoma of the Lung : A Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Case. / Cavazza, Alberto; Paci, Massimiliano; De Marco, Loredana; Leporati, Guido; Sartori, Giuliana; Bigiani, Nazzarena; Rossi, Giulio.

In: International Journal of Surgical Pathology, Vol. 12, No. 2, 04.2004, p. 155-159.

Research output: Contribution to journalArticle

Cavazza, Alberto ; Paci, Massimiliano ; De Marco, Loredana ; Leporati, Guido ; Sartori, Giuliana ; Bigiani, Nazzarena ; Rossi, Giulio. / Alveolar Adenoma of the Lung : A Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Case. In: International Journal of Surgical Pathology. 2004 ; Vol. 12, No. 2. pp. 155-159.
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