Alveolar-capillary membrane dysfunction in chronic heart failure: Pathophysiology and therapeutic implications

Research output: Contribution to journalArticle

Abstract

Chronic heart failure (CHF) disturbs the alveolar-capillary interface and increases the resistance to gas transfer. Alveolar-capillary membrane conductance (D(M)) and capillary blood volume (V(c)) are subcomponents of the lung diffusion capacity. Elevation of the capillary pressure causes alveolar-capillary membrane stress failure (i.e. increase in capillary permeability to water and ions, and disruption of local regulatory mechanisms for gas exchange), leading to a decrease in D(M), an increase in V(c) and subsequent impairment of diffusion capacity. Renewed recent interest in abnormalities in lung diffusion in patients with CHF has brought about new pathophysiological insights. A significant contribution of the altered gas transfer to the pathogenesis of exercise limitation and ventilatory abnormalities has been reported, and D(M) has been identified as the best lung function predictor of oxygen uptake at peak exercise. This review examines the pathophysiological and clinical significance of assessing lung diffusion capacity in patients with CHF.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalClinical Science
Volume98
Issue number6
Publication statusPublished - 2000

Fingerprint

Heart Failure
Membranes
Lung Volume Measurements
Gases
Exercise
Therapeutics
Lung
Capillary Permeability
Blood Volume
Ions
Oxygen
Pressure
Water

Keywords

  • Gas diffusion
  • Heart failure
  • Pulmonary function

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alveolar-capillary membrane dysfunction in chronic heart failure : Pathophysiology and therapeutic implications. / Guazzi, Marco.

In: Clinical Science, Vol. 98, No. 6, 2000, p. 633-641.

Research output: Contribution to journalArticle

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