Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro.

A. Antinori, E. Tamburrini, G. Pagliari, G. Maiuro, F. Pallavicini, A. De Luca, L. Ortona

Research output: Contribution to journalArticle

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Abstract

In vitro production of TNF-alpha by alveolar macrophages was investigated in 15 AIDS patients with acute interstitial pneumonia and in 4 patients with asymptomatic HIV infection (anti-HIV+) and was compared to that observed in 6 patients with chronic pulmonary disease and in 5 normal controls (undergoing a fiberoptic bronchoscopy for suspected lung malignancy), all 11 HIV negative. Our results show that unstimulated alveolar macrophages of AIDS and anti-HIV+ patients released much more TNF-alpha than subjects with chronic obstructive pulmonary disease or healthy controls did: this overproduction may play a role in the pathogenesis of lung damage infection and particularly in AIDS patients.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalAllergologia et Immunopathologia
Volume20
Issue number6
Publication statusPublished - Nov 1992

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Alveolar Macrophages
Acquired Immunodeficiency Syndrome
Tumor Necrosis Factor-alpha
HIV
Lung
Asymptomatic Infections
Interstitial Lung Diseases
Bronchoscopy
Chronic Obstructive Pulmonary Disease
Lung Diseases
HIV Infections
Chronic Disease
In Vitro Techniques
Infection
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Antinori, A., Tamburrini, E., Pagliari, G., Maiuro, G., Pallavicini, F., De Luca, A., & Ortona, L. (1992). Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro. Allergologia et Immunopathologia, 20(6), 249-254.

Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro. / Antinori, A.; Tamburrini, E.; Pagliari, G.; Maiuro, G.; Pallavicini, F.; De Luca, A.; Ortona, L.

In: Allergologia et Immunopathologia, Vol. 20, No. 6, 11.1992, p. 249-254.

Research output: Contribution to journalArticle

Antinori, A, Tamburrini, E, Pagliari, G, Maiuro, G, Pallavicini, F, De Luca, A & Ortona, L 1992, 'Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro.', Allergologia et Immunopathologia, vol. 20, no. 6, pp. 249-254.
Antinori A, Tamburrini E, Pagliari G, Maiuro G, Pallavicini F, De Luca A et al. Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro. Allergologia et Immunopathologia. 1992 Nov;20(6):249-254.
Antinori, A. ; Tamburrini, E. ; Pagliari, G. ; Maiuro, G. ; Pallavicini, F. ; De Luca, A. ; Ortona, L. / Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro. In: Allergologia et Immunopathologia. 1992 ; Vol. 20, No. 6. pp. 249-254.
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