Alveolar macrophages from AIDS patients spontaneously produce elevated levels of TNF-alpha in vitro.

A. Antinori, E. Tamburrini, G. Pagliari, G. Maiuro, F. Pallavicini, A. De Luca, L. Ortona

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro production of TNF-alpha by alveolar macrophages was investigated in 15 AIDS patients with acute interstitial pneumonia and in 4 patients with asymptomatic HIV infection (anti-HIV+) and was compared to that observed in 6 patients with chronic pulmonary disease and in 5 normal controls (undergoing a fiberoptic bronchoscopy for suspected lung malignancy), all 11 HIV negative. Our results show that unstimulated alveolar macrophages of AIDS and anti-HIV+ patients released much more TNF-alpha than subjects with chronic obstructive pulmonary disease or healthy controls did: this overproduction may play a role in the pathogenesis of lung damage infection and particularly in AIDS patients.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalAllergologia et Immunopathologia
Volume20
Issue number6
Publication statusPublished - Nov 1992

ASJC Scopus subject areas

  • Immunology and Allergy

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