Alveolar socket preservation with demineralised bovine bone mineral and a collagen matrix

Carlo Maiorana, Pier Paolo Poli, Matteo Deflorian, Tiziano Testori, Federico Mandelli, Heiner Nagursky, Raffaele Vinci

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of the present study was to evaluate the healing of post-extraction sockets following alveolar ridge preservation clinically, radiologically, and histologically. Methods: Overall, 7 extraction sockets in 7 patients were grafted with demineralised bovine bone mineral and covered with a porcine-derived non-crosslinked collagen matrix (CM). Soft tissue healing was clinically evaluated on the basis of a specific healing index. Horizontal and vertical ridge dimensional changes were assessed clinically and radiographically at baseline and 6 months after implant placement. For histological and histomorphometric analysis, bone biopsies were harvested from the augmented sites during implant surgery 6 months after the socket preservation procedure. Results: Clinically, healing proceeded uneventfully in all the sockets. A trend towards reduced horizontal and vertical socket dimensions was observed from baseline to the final examination. The mean width and height of resorption were 1.21 mm (P=0.005) and 0.46 mm (P=0.004), respectively. Histologically, residual xenograft particles (31.97%±3.52%) were surrounded by either newly formed bone (16.02%±7.06%) or connective tissue (50.67%±8.42%) without fibrous encapsulation. The CM underwent a physiological substitution process in favour of well-vascularised collagen-rich connective tissue. Conclusions: Socket preservation using demineralised bovine bone mineral in combination with CM provided stable dimensional changes of the alveolar ridge associated with good re-epithelialisation of the soft tissues during a 6-month healing period.

Original languageEnglish
Pages (from-to)194-210
Number of pages17
JournalJournal of Periodontal and Implant Science
Volume47
Issue number4
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Bone regeneration
  • Bone substitutes
  • Histology
  • Tooth loss

ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics

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