Alveolar Soft-Part Sarcoma of the Tongue

Victoria Alegría-Landa, Viviana Lora, Carlo Cota, Heinz Kutzner, Luis Requena

Research output: Contribution to journalArticlepeer-review


Alveolar soft-part sarcoma is a rare neoplasm of unknown histogenesis that accounts for less than 1% of all soft-tissue sarcomas. The tumor is highly vascularized with small vascular spaces separating nests of cells, and from cytogenetic point of view, is characterized by chromosome rearrangement der(17)t(X:17)(p11:q25) that results in the ASPL-TFE3 translocation. It can occur at any age, but it is most common between 15 and 35 years of age. The prognosis is poor, despite the relatively slow growth of the tumor. We present here an atypical case of alveolar soft-part sarcoma in which the age of the patient, the location, and the histopathologic characteristics of the lesion represented a diagnostic challenge.

Original languageEnglish
Pages (from-to)218-220
Number of pages3
JournalThe American Journal of dermatopathology
Issue number3
Publication statusPublished - Mar 2019


  • Biomarkers, Tumor/analysis
  • Biopsy
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Sarcoma, Alveolar Soft Part/chemistry
  • Tongue Neoplasms/chemistry

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