Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism

D. Seripa, M. G. Matera, R. P. D'Andrea, C. Gravina, C. Masullo, A. Daniele, A. Bizzarro, M. Rinaldi, P. Antuono, D. R. Wekstein, G. Dal Forno, V. M. Fazio

Research output: Contribution to journalArticle

Abstract

The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.

Original languageEnglish
Pages (from-to)1631-1633
Number of pages3
JournalNeurology
Volume62
Issue number9
Publication statusPublished - May 11 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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    Seripa, D., Matera, M. G., D'Andrea, R. P., Gravina, C., Masullo, C., Daniele, A., Bizzarro, A., Rinaldi, M., Antuono, P., Wekstein, D. R., Dal Forno, G., & Fazio, V. M. (2004). Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism. Neurology, 62(9), 1631-1633.