Alzheimers disease and schizophrenia: Evidence of a specific, shared molecular background

Annapaola Prestia

Research output: Contribution to journalArticlepeer-review


Evaluation of: Horesh Y, Katsel P, Haroutunian V, Domany E: Gene expression signature is shared by patients with Alzheimers disease and schizophrenia at the superior temporal gyrus. Eur. J. Neurol. DOI: 10.1111/j.1468-1331.2010. 03166.x (2010) (Epub ahead of print). This study tried to detect any molecular substrate that might be shared by brain disorders in general, comparing gene expression profiles across multiple brain areas determined by post-mortem samples from 83 patients affected by well-characterized diseases of the brain with marked differences in neuropathology, etiology and symptoms, such as Alzheimers disease (AD; n = 55) and schizophrenia (n = 28). Brodmann area 22, namely the superior temporal gyrus, had a greater number of abnormally expressed genes in both diseases; moreover, genes that differentiated AD and schizophrenia patients from normal elders (n = 22) were principally downregulated and more present in Brodmann area 8, part of the superior frontal cortex. The findings point to a specific molecular background shared by AD and schizophrenia, suggesting that impairment of the autophagy pathway regulation system could be one of the common bases of the two diseases; however, further studies are necessary, taking into account exposure to medications, sex hormone influences and with a significant expanded sample size in order to strengthen the evidence in support of the notion that at least part of the molecular background of AD and schizophrenia is shared by these two diseases.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalFuture Neurology
Issue number1
Publication statusPublished - Jan 2011


  • Alzheimers disease
  • gene expression
  • schizophrenia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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