Alzheimer's disease: From pathogenesis to disease-modifying approaches

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Abstract

The two major neuropathologic hallmarks of AD are extracellular amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). A number of additional pathogenic mechanisms, possibly overlapping with Aβ plaques and NFTs formation, have been described, including inflammation, oxidative damage, iron dysregulation, and alterations in cholesterol metabolism. In this review, all of these mechanisms will be discussed and treatments that are under development to interfere with these pathogenic steps will be presented. A primary goal of work in this area is identification of novel compounds that can blo ck the course of the disease in early phases. For this reason they are currently termed "disease modifying" drugs. These drugs are designed to modify pathological steps leading to AD, thus acting on the evolution and progression of the disease. Some of these molecules are undergoing clinical testing whereas others are in preclinical phases of development. Several approaches have been considered, including mainlyAβ deposition interference by anti- Aβ aggregation agents, vaccination, ��-secretase inhibition or selective Aβ42-lowering agents (SALAs), tau deposition interference by methyl thioninium chloride (MTC), and methods for reduction of inflammation and oxidative damage.

Original languageEnglish
Pages (from-to)163-174
Number of pages12
JournalCNS and Neurological Disorders - Drug Targets
Volume10
Issue number2
Publication statusPublished - 2011

Keywords

  • Alzheimer's disease
  • Amyloid
  • Anti-inflammatories
  • Disease-modifying drugs
  • Inflammation
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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