Alzheimer's disease linking neurodegeneration with neurodevelopment

Mariagrazia Grilli, Giulia Ferrari Toninelli, Daniela Uberti, PierFranco F. Spano, Maurizio Memo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

An association has recently been suggested between several of the genes and proteins that play a central role in early neuronal development, particularly in neuronal migration and axon elongation, and Alzheimer's disease (AD). This paper reviews the work of several investigators who have hypothesised the involvement of three pathways known to be active participants in neuronal maturation (those involving Notch, Reelin, and Wnt intracellular signalling) and also in the neurodegenerative events underlying AD. The choice of these intracellular pathways is based on the observation that there exist several points of convergence among these systems and amyloid precursor protein processing and neurofibrillary tangle formation. Pharmacological manipulation of the Notch/Wnt/Reelin intracellular signalling pathways may thus represent a novel approach to the regulation of neurodegenerative processes in AD.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalFunctional Neurology
Volume18
Issue number3
Publication statusPublished - Jul 2003

Fingerprint

Alzheimer Disease
Neurofibrillary Tangles
Amyloid beta-Protein Precursor
Axons
Research Personnel
Pharmacology
Proteins

Keywords

  • APP
  • Neurofibrillary tangles
  • Notch
  • Reelin
  • Wnt

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Grilli, M., Toninelli, G. F., Uberti, D., Spano, P. F., & Memo, M. (2003). Alzheimer's disease linking neurodegeneration with neurodevelopment. Functional Neurology, 18(3), 145-148.

Alzheimer's disease linking neurodegeneration with neurodevelopment. / Grilli, Mariagrazia; Toninelli, Giulia Ferrari; Uberti, Daniela; Spano, PierFranco F.; Memo, Maurizio.

In: Functional Neurology, Vol. 18, No. 3, 07.2003, p. 145-148.

Research output: Contribution to journalArticle

Grilli, M, Toninelli, GF, Uberti, D, Spano, PF & Memo, M 2003, 'Alzheimer's disease linking neurodegeneration with neurodevelopment', Functional Neurology, vol. 18, no. 3, pp. 145-148.
Grilli M, Toninelli GF, Uberti D, Spano PF, Memo M. Alzheimer's disease linking neurodegeneration with neurodevelopment. Functional Neurology. 2003 Jul;18(3):145-148.
Grilli, Mariagrazia ; Toninelli, Giulia Ferrari ; Uberti, Daniela ; Spano, PierFranco F. ; Memo, Maurizio. / Alzheimer's disease linking neurodegeneration with neurodevelopment. In: Functional Neurology. 2003 ; Vol. 18, No. 3. pp. 145-148.
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