TY - JOUR
T1 - Alzheimer’s disease markers from structural MRI and FDG-PET brain images
AU - Chincarini, Andrea
AU - Bosco, Paolo
AU - Gemme, Gianluca
AU - Morbelli, Silvia
AU - Arnaldi, Dario
AU - Sensi, Francesco
AU - Solano, Ilaria
AU - Amoroso, Nicola
AU - Tangaro, Sabina
AU - Longo, Renata
AU - Squarcia, Sandro
AU - Nobili, Flavio
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Despite the widespread use of neuroimaging tools (morphological and functional) in the routine diagnostic of cerebral diseases, the information available by the end user -the clinician- remains largely limited to qualitative visual analysis. This restriction greatly reduces the diagnostic impact of neuroimaging in routine clinical practice and increases the risk of misdiagnosis. In this context, researches are focussing on the development of sophisticated automatic analyses able to extract clinically relevant information from the captured data. The identification of biological markers at early stages of Alzheimer’s disease (AD) contributes to diagnostic accuracy and adds prognostic value. However, in spite of recent developments, results of structural and functional imaging studies on predicting conversion to AD are not uniform. We provide here an overview of analysis methods and approaches, discussing their contribution to clinical assessment.
AB - Despite the widespread use of neuroimaging tools (morphological and functional) in the routine diagnostic of cerebral diseases, the information available by the end user -the clinician- remains largely limited to qualitative visual analysis. This restriction greatly reduces the diagnostic impact of neuroimaging in routine clinical practice and increases the risk of misdiagnosis. In this context, researches are focussing on the development of sophisticated automatic analyses able to extract clinically relevant information from the captured data. The identification of biological markers at early stages of Alzheimer’s disease (AD) contributes to diagnostic accuracy and adds prognostic value. However, in spite of recent developments, results of structural and functional imaging studies on predicting conversion to AD are not uniform. We provide here an overview of analysis methods and approaches, discussing their contribution to clinical assessment.
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U2 - 10.1140/epjp/i2012-12135-6
DO - 10.1140/epjp/i2012-12135-6
M3 - Article
AN - SCOPUS:84964761792
VL - 127
JO - European Physical Journal Plus
JF - European Physical Journal Plus
SN - 2190-5444
IS - 11
M1 - 135
ER -