Alzheimer's Disease, Oligomers, and Inflammation

Research output: Contribution to journalArticle

Abstract

The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role of oligomers as responsible for the neuronal dysfunction associated with the clinical features has been extended to the other protein misfolding disorders definable, on this basis, as oligomeropathies. In AD, recent evidence indicates that the mechanism of inflammation as a consequence of neurodegeneration must be assessed in favor of a more direct role of glial activation in the alteration of synaptic function. Our own experimental models demonstrate the efficacy of anti-inflammatory treatments in preventing the cognitive deficits induced acutely by AβOs applied directly in the brain. Moreover, some promising clinical tools are based on immunological activation reducing the presence of cerebral Aβ deposits. However, the strategies based on the control of inflammatory factors as well as the amyloid aggregation show poor or non-therapeutic efficacy. Numerous studies have examined inflammatory factors in biological fluids as possible markers of the neuroinflammation in AD. In some cases, altered levels of cytokines or other inflammatory markers in cerebrospinal fluid correlate with the severity of the disease. Here we propose, according to the precision medicine principles, innovative therapeutic approaches to AD based on the patient's inflammatory profile/state. The earlier intervention and a multifactor approach are two other elements considered essential to improve the chances of effective therapy in AD.

Original languageEnglish
Pages (from-to)1261-1276
Number of pages16
JournalJournal of Alzheimer's disease : JAD
Volume62
Issue number3
DOIs
Publication statusPublished - 2018

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Alzheimer Disease
Inflammation
Amyloid
Proteostasis Deficiencies
Precision Medicine
Biological Factors
Neuroglia
Cerebrospinal Fluid
Anti-Inflammatory Agents
Theoretical Models
Therapeutics
Cytokines
Brain

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Alzheimer's Disease, Oligomers, and Inflammation. / Forloni, Gianluigi; Balducci, Claudia.

In: Journal of Alzheimer's disease : JAD, Vol. 62, No. 3, 2018, p. 1261-1276.

Research output: Contribution to journalArticle

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