TY - JOUR
T1 - Ambient air pollution and adult asthma incidence in six european cohorts (Escape)
AU - Jacquemin, Bénédicte
AU - Siroux, Valérie
AU - Sanchez, Margaux
AU - Carsin, Anne Elie
AU - Schikowski, Tamara
AU - Adam, Martin
AU - Bellisario, Valeria
AU - Buschka, Anna
AU - Bono, Roberto
AU - Brunekreef, Bert
AU - Cai, Yutong
AU - Cirach, Marta
AU - Clavel-Chapelon, Françoise
AU - Declercq, Christophe
AU - de Marco, Roberto
AU - De Nazelle, Audrey
AU - Ducret-Stich, Regina E.
AU - Ferretti, Virginia Valeria
AU - Gerbase, Margaret W.
AU - Hardy, Rebecca
AU - Heinrich, Joachim
AU - Janson, Christer
AU - Jarvis, Deborah
AU - Al Kanaani, Zaina
AU - Keidel, Dirk
AU - Kuh, Diana
AU - Le Moual, Nicole
AU - Nieuwenhuijsen, Mark J.
AU - Marcon, Alessandro
AU - Modig, Lars
AU - Pin, Isabelle
AU - Rochat, Thierry
AU - Schindler, Christian
AU - Sugiri, Dorothea
AU - Stempfelet, Morgane
AU - Temam, Sofia
AU - Tsai, Ming Yi
AU - Varraso, Raphaëlle
AU - Vienneau, Danielle
AU - Vierkötter, Andrea
AU - Hansell, Anna L.
AU - Krämer, Ursula
AU - Probst-Hensch, Nicole M.
AU - Sunyer, Jordi
AU - Künzli, Nino
AU - Kauffmann, Francine
PY - 2015
Y1 - 2015
N2 - Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10−5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.
AB - Background: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. Objective: We aimed to investigate the association between air pollution and adult onset asthma. Methods: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. Results: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 μg/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 μg/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 μg/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 μg/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10−5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles × meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative associa-tion was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 μg/m3). Conclusions: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed.
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U2 - 10.1289/ehp.1408206
DO - 10.1289/ehp.1408206
M3 - Article
AN - SCOPUS:84930511193
VL - 123
SP - 613
EP - 621
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 6
ER -