Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M. Bianchi; A. Mantovani; A. Erroi; C. A. Dinarello; P. Ghezzi

doi:10.1007/BF01997619

Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M. Bianchi, A. Mantovani, A. Erroi, C. A. Dinarello, P. Ghezzi

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.

Original language	English
Pages (from-to)	275-279
Number of pages	5
Journal	Agents and Actions
Volume	31
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01997619
Publication status	Published - Nov 1990

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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title = "Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells",

abstract = "We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.",

author = "M. Bianchi and A. Mantovani and A. Erroi and Dinarello, {C. A.} and P. Ghezzi",

year = "1990",

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AU - Bianchi, M.

AU - Mantovani, A.

AU - Erroi, A.

AU - Dinarello, C. A.

AU - Ghezzi, P.

PY - 1990/11

Y1 - 1990/11

N2 - We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.

AB - We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.

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Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

Abstract

ASJC Scopus subject areas

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