Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M. Bianchi, A. Mantovani, A. Erroi, C. A. Dinarello, P. Ghezzi

Research output: Contribution to journalArticle

Abstract

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalAgents and Actions
Volume31
Issue number3-4
DOIs
Publication statusPublished - Nov 1990

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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