Abstract
We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 μg/ml, without any apparent toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 275-279 |
| Number of pages | 5 |
| Journal | Agents and Actions |
| Volume | 31 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Nov 1990 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)
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Bianchi, M., Mantovani, A., Erroi, A., Dinarello, C. A., & Ghezzi, P. (1990). Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells. Agents and Actions, 31(3-4), 275-279. https://doi.org/10.1007/BF01997619