Ambulatory 24-h esophageal pH monitoring: Normal values, optimal thresholds, specificity, sensitivity, and reproducibility

J. R. Jamieson, H. J. Stein, T. R. DeMeester, L. Bonavina, W. Schwizer, R. A. Hinder, M. Albertucci

Research output: Contribution to journalArticle

446 Citations (Scopus)

Abstract

Ambulatory 24-h esophageal pH monitoring is increasing in popularity as the means to measure esophageal exposure to gastric juice and document the presence of gastroesophageal reflux disease, particularly before surgical therapy. Normal values for pH exposure were obtained from 50 asymptomatic healthy subjects. Receiver operating characteristic curves constructed from another 25 asymptomatic healthy subjects and 25 selected patients with other markers of increased esophageal acid exposure showed that a composite score and the percent total time pH <4 provide the most efficient interpretation of the test with a sensitivity of 96%, a specificity of 100% and an accuracy of 98% for the composite score, and a sensitivity, specificity, and accuracy of 96% for the percent total time pH <4. Repeat monitoring of healthy volunteers and symptomatic subjects in the inpatient and outpatient environment showed no significant difference, with the exception that the number of reflux episodes was significantly greater during the outpatient recording in volunteers. This did not affect the clinical accuracy of the test. Esophageal pH probes were well tolerated, but caused belching and coughing during the early part of the monitored period. We conclude that computerized ambulatory 24-h esophageal pH monitoring in the outpatient setting provides accurate and reproducible results.

Original languageEnglish
Pages (from-to)1102-1111
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume87
Issue number9
Publication statusPublished - 1992

Fingerprint

Esophageal pH Monitoring
Reference Values
Sensitivity and Specificity
Healthy Volunteers
Outpatients
Eructation
Gastric Juice
Gastroesophageal Reflux
ROC Curve
Inpatients
Volunteers
Acids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Jamieson, J. R., Stein, H. J., DeMeester, T. R., Bonavina, L., Schwizer, W., Hinder, R. A., & Albertucci, M. (1992). Ambulatory 24-h esophageal pH monitoring: Normal values, optimal thresholds, specificity, sensitivity, and reproducibility. American Journal of Gastroenterology, 87(9), 1102-1111.

Ambulatory 24-h esophageal pH monitoring : Normal values, optimal thresholds, specificity, sensitivity, and reproducibility. / Jamieson, J. R.; Stein, H. J.; DeMeester, T. R.; Bonavina, L.; Schwizer, W.; Hinder, R. A.; Albertucci, M.

In: American Journal of Gastroenterology, Vol. 87, No. 9, 1992, p. 1102-1111.

Research output: Contribution to journalArticle

Jamieson, JR, Stein, HJ, DeMeester, TR, Bonavina, L, Schwizer, W, Hinder, RA & Albertucci, M 1992, 'Ambulatory 24-h esophageal pH monitoring: Normal values, optimal thresholds, specificity, sensitivity, and reproducibility', American Journal of Gastroenterology, vol. 87, no. 9, pp. 1102-1111.
Jamieson, J. R. ; Stein, H. J. ; DeMeester, T. R. ; Bonavina, L. ; Schwizer, W. ; Hinder, R. A. ; Albertucci, M. / Ambulatory 24-h esophageal pH monitoring : Normal values, optimal thresholds, specificity, sensitivity, and reproducibility. In: American Journal of Gastroenterology. 1992 ; Vol. 87, No. 9. pp. 1102-1111.
@article{d3b0b1fd6f7140d4ad3b806a1ba03c27,
title = "Ambulatory 24-h esophageal pH monitoring: Normal values, optimal thresholds, specificity, sensitivity, and reproducibility",
abstract = "Ambulatory 24-h esophageal pH monitoring is increasing in popularity as the means to measure esophageal exposure to gastric juice and document the presence of gastroesophageal reflux disease, particularly before surgical therapy. Normal values for pH exposure were obtained from 50 asymptomatic healthy subjects. Receiver operating characteristic curves constructed from another 25 asymptomatic healthy subjects and 25 selected patients with other markers of increased esophageal acid exposure showed that a composite score and the percent total time pH <4 provide the most efficient interpretation of the test with a sensitivity of 96{\%}, a specificity of 100{\%} and an accuracy of 98{\%} for the composite score, and a sensitivity, specificity, and accuracy of 96{\%} for the percent total time pH <4. Repeat monitoring of healthy volunteers and symptomatic subjects in the inpatient and outpatient environment showed no significant difference, with the exception that the number of reflux episodes was significantly greater during the outpatient recording in volunteers. This did not affect the clinical accuracy of the test. Esophageal pH probes were well tolerated, but caused belching and coughing during the early part of the monitored period. We conclude that computerized ambulatory 24-h esophageal pH monitoring in the outpatient setting provides accurate and reproducible results.",
author = "Jamieson, {J. R.} and Stein, {H. J.} and DeMeester, {T. R.} and L. Bonavina and W. Schwizer and Hinder, {R. A.} and M. Albertucci",
year = "1992",
language = "English",
volume = "87",
pages = "1102--1111",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Ambulatory 24-h esophageal pH monitoring

T2 - Normal values, optimal thresholds, specificity, sensitivity, and reproducibility

AU - Jamieson, J. R.

AU - Stein, H. J.

AU - DeMeester, T. R.

AU - Bonavina, L.

AU - Schwizer, W.

AU - Hinder, R. A.

AU - Albertucci, M.

PY - 1992

Y1 - 1992

N2 - Ambulatory 24-h esophageal pH monitoring is increasing in popularity as the means to measure esophageal exposure to gastric juice and document the presence of gastroesophageal reflux disease, particularly before surgical therapy. Normal values for pH exposure were obtained from 50 asymptomatic healthy subjects. Receiver operating characteristic curves constructed from another 25 asymptomatic healthy subjects and 25 selected patients with other markers of increased esophageal acid exposure showed that a composite score and the percent total time pH <4 provide the most efficient interpretation of the test with a sensitivity of 96%, a specificity of 100% and an accuracy of 98% for the composite score, and a sensitivity, specificity, and accuracy of 96% for the percent total time pH <4. Repeat monitoring of healthy volunteers and symptomatic subjects in the inpatient and outpatient environment showed no significant difference, with the exception that the number of reflux episodes was significantly greater during the outpatient recording in volunteers. This did not affect the clinical accuracy of the test. Esophageal pH probes were well tolerated, but caused belching and coughing during the early part of the monitored period. We conclude that computerized ambulatory 24-h esophageal pH monitoring in the outpatient setting provides accurate and reproducible results.

AB - Ambulatory 24-h esophageal pH monitoring is increasing in popularity as the means to measure esophageal exposure to gastric juice and document the presence of gastroesophageal reflux disease, particularly before surgical therapy. Normal values for pH exposure were obtained from 50 asymptomatic healthy subjects. Receiver operating characteristic curves constructed from another 25 asymptomatic healthy subjects and 25 selected patients with other markers of increased esophageal acid exposure showed that a composite score and the percent total time pH <4 provide the most efficient interpretation of the test with a sensitivity of 96%, a specificity of 100% and an accuracy of 98% for the composite score, and a sensitivity, specificity, and accuracy of 96% for the percent total time pH <4. Repeat monitoring of healthy volunteers and symptomatic subjects in the inpatient and outpatient environment showed no significant difference, with the exception that the number of reflux episodes was significantly greater during the outpatient recording in volunteers. This did not affect the clinical accuracy of the test. Esophageal pH probes were well tolerated, but caused belching and coughing during the early part of the monitored period. We conclude that computerized ambulatory 24-h esophageal pH monitoring in the outpatient setting provides accurate and reproducible results.

UR - http://www.scopus.com/inward/record.url?scp=0026675024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026675024&partnerID=8YFLogxK

M3 - Article

C2 - 1519566

AN - SCOPUS:0026675024

VL - 87

SP - 1102

EP - 1111

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 9

ER -