Ambulatory blood pressure and diabetes: Targeting nondipping

Cesare Cuspidi, Alvaro Vaccarella, Gastone Leonetti, Carla Sala

Research output: Contribution to journalArticlepeer-review


A reduced fall in nocturnal blood pressure (BP) (i.e. non-dipping) has been related to an increase in target organ damage and cardiovascular (CV) events. Numerous studies have shown that non-dipping is highly prevalent in patients with type 1 and 2 diabetes mellitus. In this paper we reviewed recent literature and our personal data on the prevalence and clinical correlates of abnormal diurnal BP rhythm in diabetic patients; in particular we examined the association of this condition with renal, cardiac, and vascular preclinical organ damage as well as CV prognosis. A consistent body of evidence based on cross-sectional and longitudinal studies indicates that the lack of the physiologic nocturnal fall in BP may be considered a true clinical trait, a reliable marker of preclinical CV and renal disease and an independent predictor of future CV events. Thus, in the diabetic setting ambulatory BP monitoring (ABPM) should be regarded as a pivotal tool for improving CV risk stratification and therapeutic interventions.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalCurrent Diabetes Reviews
Issue number2
Publication statusPublished - Mar 2010


  • Cardiovascular prognosis
  • Diabetes mellitus type 1 and 2
  • Hypertension
  • Non-dipping
  • Organ damage

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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