TY - JOUR
T1 - Ambulatory Blood Pressure in Untreated and Treated Hypertensive Patients at High Altitude
T2 - The High Altitude Cardiovascular Research-Andes Study
AU - Bilo, Grzegorz
AU - Villafuerte, Francisco C.
AU - Faini, Andrea
AU - Anza-Ramírez, Cecilia
AU - Revera, Miriam
AU - Giuliano, Andrea
AU - Caravita, Sergio
AU - Gregorini, Francesca
AU - Lombardi, Carolina
AU - Salvioni, Elisabetta
AU - Macarlupu, Jose Luis
AU - Ossoli, Deborah
AU - Landaveri, Leah
AU - Lang, Morin
AU - Agostoni, Piergiuseppe
AU - Sosa, José Manuel
AU - Mancia, Giuseppe
AU - Parati, Gianfranco
PY - 2015/6/20
Y1 - 2015/6/20
N2 - Blood pressure increases during acute exposure to high altitude in healthy humans. However, little is known on altitude effects in hypertensive subjects or on the treatment efficacy in this condition. Objectives of High Altitude Cardiovascular Research (HIGHCARE)-Andes Lowlanders Study were to investigate the effects of acute high-altitude exposure on 24-hour ambulatory blood pressure in hypertensive subjects and to assess antihypertensive treatment efficacy in this setting. One hundred untreated subjects with mild hypertension (screening blood pressure, 144.1±9.8 mm Hg systolic, 92.0±7.5 mm Hg diastolic) were randomized to double-blind placebo or to telmisartan 80 mg+modified release nifedipine 30 mg combination. Twenty-four-hour ambulatory blood pressure monitoring was performed off-treatment, after 6 weeks of treatment at sea level, on treatment during acute exposure to high altitude (3260 m) and immediately after return to sea level. Eighty-nine patients completed the study (age, 56.4±17.6 years; 52 men/37 women; body mass index, 28.2±3.5 kg/m 2). Twenty-four-hour systolic blood pressure increased at high altitude in both groups (placebo, 11.0±9 mm Hg; P
AB - Blood pressure increases during acute exposure to high altitude in healthy humans. However, little is known on altitude effects in hypertensive subjects or on the treatment efficacy in this condition. Objectives of High Altitude Cardiovascular Research (HIGHCARE)-Andes Lowlanders Study were to investigate the effects of acute high-altitude exposure on 24-hour ambulatory blood pressure in hypertensive subjects and to assess antihypertensive treatment efficacy in this setting. One hundred untreated subjects with mild hypertension (screening blood pressure, 144.1±9.8 mm Hg systolic, 92.0±7.5 mm Hg diastolic) were randomized to double-blind placebo or to telmisartan 80 mg+modified release nifedipine 30 mg combination. Twenty-four-hour ambulatory blood pressure monitoring was performed off-treatment, after 6 weeks of treatment at sea level, on treatment during acute exposure to high altitude (3260 m) and immediately after return to sea level. Eighty-nine patients completed the study (age, 56.4±17.6 years; 52 men/37 women; body mass index, 28.2±3.5 kg/m 2). Twenty-four-hour systolic blood pressure increased at high altitude in both groups (placebo, 11.0±9 mm Hg; P
KW - altitude
KW - anoxia
KW - antihypertensive agents
KW - blood pressure
KW - blood pressure monitoring, ambulatory
UR - http://www.scopus.com/inward/record.url?scp=84931024767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931024767&partnerID=8YFLogxK
U2 - 10.1161/HYPERTENSIONAHA.114.05003
DO - 10.1161/HYPERTENSIONAHA.114.05003
M3 - Article
C2 - 25895588
AN - SCOPUS:84931024767
VL - 65
SP - 1266
EP - 1272
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 6
ER -