Ambulatory pressure decreases on long-term placebo treatment in older patients with isolated systolic hypertension

Jan A. Staessen, Lutgarde Thijs, Denis Clement, Christopher Davidson, Robert Fagard, Aapo Lehtonen, Giuseppe Mancia, Paolo Palatini, Eoin T. O'Brien, Gianfranco Parati, John Webster

Research output: Contribution to journalArticle

Abstract

Objective: This long-term study investigated the widely accepted hypothesis that ambulatory pressure does not decrease in patients given placebo. Methods: One hundred and twelve older (=60 years) outpatients with isolated systolic hypertension were recruited. Treatment consisted of a placebo during a 3-month baseline period and long-term follow-up. Results: At baseline, on placebo treatment, clinic systolic/diastolic (SBP/DBP) blood pressure (±SD) averaged 176±12/86±7mmHg and 24-h SBP/DBP 151 ± 15/81 ± 10 mmHg. These pressures were unaltered in 51 patients in whom the baseline measurements were repeated after a further month on placebo. After the 112 patients had received placebo for 1 year (median), clinic SBP/DBP fell by 6.6±15.9 (P

Original languageEnglish
Pages (from-to)1035-1039
Number of pages5
JournalJournal of Hypertension
Volume12
Issue number9
Publication statusPublished - 1994

Keywords

  • Ambulatory blood pressure
  • Conventional blood pressure
  • Placebo

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

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    Staessen, J. A., Thijs, L., Clement, D., Davidson, C., Fagard, R., Lehtonen, A., Mancia, G., Palatini, P., O'Brien, E. T., Parati, G., & Webster, J. (1994). Ambulatory pressure decreases on long-term placebo treatment in older patients with isolated systolic hypertension. Journal of Hypertension, 12(9), 1035-1039.