Amelanotic cutaneous melanoma: Case reports and considerations

R. Betti, R. Vergani, M. Palvarini, E. Inselvini, C. Pazzini, C. Crosti

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In our study, we investigated the history of ten patients with amelanotic melanomas and considered the clinical aspect of the lesions and the difficulty in diagnosis, in order to discuss the possible delay in their diagnosis. The tumours regarded elderly patents (mean age 57.9 years), without significant difference betWeen sexes. Lower limbs were the preferential site (80%), the mean thickness was 2.9 min. We also found an average of 15.9 months of delay in diagnosis (vs 8 months in patients with pigmented melanoma). Amelanotic melanoma is easily confused with epithelial tumour or dermatitis, but when a lesion cannot be included among any usual presentations of the former, and does not respond to the routine treatment, the diagnosis of amelanotic melanoma should be taken into account. Moreover, the delay in diagnosis may contribute to the thickness of the tumour and to the poor prognosis.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalSkin Cancer
Issue number1
Publication statusPublished - 1999


  • Amelanotic melanoma
  • Delayed diagnosis

ASJC Scopus subject areas

  • Dermatology
  • Oncology


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