Abstract
Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.
| Original language | English |
|---|---|
| Pages (from-to) | 88-93 |
| Number of pages | 6 |
| Journal | Dermatology |
| Volume | 193 |
| Issue number | 2 |
| Publication status | Published - 1996 |
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Keywords
- Autoimmune diseases
- Lupus erythematosus
- Neutrophilic dermatoses
- Neutrophils
- Subcorneal pustular dermatosis
ASJC Scopus subject areas
- Dermatology
Cite this
Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders : A new entity? / Marzano, A. V.; Capsoni, F.; Berti, E.; Gasparini, G.; Bottelli, S.; Caputo, R.
In: Dermatology, Vol. 193, No. 2, 1996, p. 88-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders
T2 - A new entity?
AU - Marzano, A. V.
AU - Capsoni, F.
AU - Berti, E.
AU - Gasparini, G.
AU - Bottelli, S.
AU - Caputo, R.
PY - 1996
Y1 - 1996
N2 - Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.
AB - Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.
KW - Autoimmune diseases
KW - Lupus erythematosus
KW - Neutrophilic dermatoses
KW - Neutrophils
KW - Subcorneal pustular dermatosis
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M3 - Article
VL - 193
SP - 88
EP - 93
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 2
ER -