Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders

A new entity?

A. V. Marzano, F. Capsoni, E. Berti, G. Gasparini, S. Bottelli, R. Caputo

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalDermatology
Volume193
Issue number2
Publication statusPublished - 1996

Fingerprint

Skin Diseases
Neutrophils
Skin
Cutaneous Lupus Erythematosus
Skin Manifestations
Direct Fluorescent Antibody Technique
Immunologic Tests
Ear Canal
Cimetidine
Celiac Disease
Chemotaxis
Scalp
Systemic Lupus Erythematosus
Autoantibodies
Ascorbic Acid
Serum
Pharmaceutical Preparations

Keywords

  • Autoimmune diseases
  • Lupus erythematosus
  • Neutrophilic dermatoses
  • Neutrophils
  • Subcorneal pustular dermatosis

ASJC Scopus subject areas

  • Dermatology

Cite this

Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders : A new entity? / Marzano, A. V.; Capsoni, F.; Berti, E.; Gasparini, G.; Bottelli, S.; Caputo, R.

In: Dermatology, Vol. 193, No. 2, 1996, p. 88-93.

Research output: Contribution to journalArticle

Marzano, AV, Capsoni, F, Berti, E, Gasparini, G, Bottelli, S & Caputo, R 1996, 'Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders: A new entity?', Dermatology, vol. 193, no. 2, pp. 88-93.
Marzano, A. V. ; Capsoni, F. ; Berti, E. ; Gasparini, G. ; Bottelli, S. ; Caputo, R. / Amicrobial pustular dermatosis of cutaneous folds associated with autoimmune disorders : A new entity?. In: Dermatology. 1996 ; Vol. 193, No. 2. pp. 88-93.
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abstract = "Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.",
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AB - Background: An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described. Objective: We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity. Methods: Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient. Results: We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria. Conclusions: All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.

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