Amicrobial pustulosis of the folds: Report of 6 cases and a literature review

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Amicrobial pustulosis of the folds (APF) is a rare entity characterized by relapsing pustular lesions involving mainly the cutaneous folds. The disease typically occurs in the context of an autoimmune disorder and is classified within the spectrum of neutrophilic dermatoses. Objective: We studied 6 young females having APF associated with various autoimmune diseases or with the presence of serum autoantibodies and reviewed the literature, in order to give a clinical overview on this syndrome. Methods: Various routine and immunological laboratory tests, histopathological examination as well as direct and indirect immunofluorescence examinations were performed. In vitro neutrophil function was evaluated in 5 cases. We report our findings and compare our cases with those published in the literature. Results: Clinically, at least one major fold and at least one minor fold as well as the anogenital area were always involved. We documented an impaired neutrophil chemotaxis in 2 subjects, neutrophil dysfunction, thus failing to be a verifying criterion. Conclusion: APF is a neutrophilic dermatosis affecting young females, which usually shows a benign clinical behavior. Although systemic corticosteroids are the most widely used therapeutic agents, we suggest that the combination of cimetidine and ascorbic acid represents a safe alternative, which may induce long-lasting clinical remission.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalDermatology
Volume216
Issue number4
DOIs
Publication statusPublished - May 2008

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Neutrophils
Skin Diseases
Direct Fluorescent Antibody Technique
Immunologic Tests
Cimetidine
Chemotaxis
Indirect Fluorescent Antibody Technique
Autoantibodies
Autoimmune Diseases
Ascorbic Acid
Adrenal Cortex Hormones
Skin
Serum
Therapeutics
In Vitro Techniques

Keywords

  • Amicrobial pustulosis of the folds
  • Ascorbic acid
  • Autoimmune disorders
  • Cimetidine
  • Lupus erythematosus

ASJC Scopus subject areas

  • Dermatology

Cite this

Amicrobial pustulosis of the folds : Report of 6 cases and a literature review. / Marzano, Angelo V.; Ramoni, Stefano; Caputo, Ruggero.

In: Dermatology, Vol. 216, No. 4, 05.2008, p. 305-311.

Research output: Contribution to journalArticle

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