Amineptine: Its effect on the dopaminergic system of rats

F. Ponzio, G. Achilli, S. Garattini, C. Perego, G. Sacchetti, S. Algeri

Research output: Contribution to journalArticlepeer-review

Abstract

3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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