3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.
|Number of pages||3|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - 1986|
ASJC Scopus subject areas
- Pharmaceutical Science