Amineptine: Its effect on the dopaminergic system of rats

F. Ponzio, G. Achilli, S. Garattini, C. Perego, G. Sacchetti, S. Algeri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

3-Methoxytyramine formation was enhanced by amineptine (40 mg kg-1 i.p.) in the striatum and limbic area, indicating an increase in the concentration of dopamine in the extraneuronal space. Since dopamine turnover, determined as the rate of L-dopa accumulation, is reduced by the drug at short (10 min) times, the enhanced extraneuronal dopamine concentration seems mainly related to amineptine-induced inhibition of its uptake.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number4
Publication statusPublished - 1986

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amineptin
Dopamine
Levodopa
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Ponzio, F., Achilli, G., Garattini, S., Perego, C., Sacchetti, G., & Algeri, S. (1986). Amineptine: Its effect on the dopaminergic system of rats. Journal of Pharmacy and Pharmacology, 38(4), 301-303.

Amineptine : Its effect on the dopaminergic system of rats. / Ponzio, F.; Achilli, G.; Garattini, S.; Perego, C.; Sacchetti, G.; Algeri, S.

In: Journal of Pharmacy and Pharmacology, Vol. 38, No. 4, 1986, p. 301-303.

Research output: Contribution to journalArticle

Ponzio, F, Achilli, G, Garattini, S, Perego, C, Sacchetti, G & Algeri, S 1986, 'Amineptine: Its effect on the dopaminergic system of rats', Journal of Pharmacy and Pharmacology, vol. 38, no. 4, pp. 301-303.
Ponzio F, Achilli G, Garattini S, Perego C, Sacchetti G, Algeri S. Amineptine: Its effect on the dopaminergic system of rats. Journal of Pharmacy and Pharmacology. 1986;38(4):301-303.
Ponzio, F. ; Achilli, G. ; Garattini, S. ; Perego, C. ; Sacchetti, G. ; Algeri, S. / Amineptine : Its effect on the dopaminergic system of rats. In: Journal of Pharmacy and Pharmacology. 1986 ; Vol. 38, No. 4. pp. 301-303.
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