Amino Acid-based Formula in Cowʼs Milk Allergy: Long-term Effects on Body Growth and Protein Metabolism. A Randomized Trial

Roberto Berni Canani, Rita Nocerino, Tullio Frediani, Sandra Lucarelli, Carmen Di Scala, Elena Varin, Ludovica Leone, Antonella Muraro, Carlo Agostoni

Research output: Contribution to journalArticle

Abstract

OBJECTIVES:: The long-term effects of amino acid–based formula (AAF) in the treatment of cowʼs milk allergy (CMA) is largely unexplored. This study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolysed whey formula (eHWF), and healthy controls (HCs). METHODS:: A 12-month multicentre randomised control trial (RCT) was conducted in outpatients with CMA (aged 5–12 m) randomised in two groups, treated with AAF (Group 1) and eHWF (Group 2), and compared with HCs (Group 3) fed with follow-on (if age 12 m). At enrolment (T0), after 3 (T3), 6 (T6) and 12 months (T12) a clinical evaluation was performed. At T0 and T3, were dosed in CMA subjects serum levels of albumin, urea, total protein, retinol binding protein, and insulin-like growth factor 1 (IGF-1). RESULTS:: 21 subjects in Group 1 (61.9% male, aged 6.5?±?1.5?m), 19 in Group 2 (57.9% male, aged 7?±?1.7?m) and 25 subjects in Group 3 (48% male, aged 5.5?±?0.5?m) completed the study. At T0, the weight z-score was similar in Group 1 (−0.74) and 2 (−0.76), with differences compared to Group 3 (−0.17, p?

Original languageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
Publication statusAccepted/In press - Jul 20 2016

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Amino Acid-based Formula in Cowʼs Milk Allergy: Long-term Effects on Body Growth and Protein Metabolism. A Randomized Trial'. Together they form a unique fingerprint.

  • Cite this