OBJECTIVES:: The long-term effects of amino acid–based formula (AAF) in the treatment of cowʼs milk allergy (CMA) is largely unexplored. This study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolysed whey formula (eHWF), and healthy controls (HCs). METHODS:: A 12-month multicentre randomised control trial (RCT) was conducted in outpatients with CMA (aged 5–12 m) randomised in two groups, treated with AAF (Group 1) and eHWF (Group 2), and compared with HCs (Group 3) fed with follow-on (if age 12 m). At enrolment (T0), after 3 (T3), 6 (T6) and 12 months (T12) a clinical evaluation was performed. At T0 and T3, were dosed in CMA subjects serum levels of albumin, urea, total protein, retinol binding protein, and insulin-like growth factor 1 (IGF-1). RESULTS:: 21 subjects in Group 1 (61.9% male, aged 6.5?±?1.5?m), 19 in Group 2 (57.9% male, aged 7?±?1.7?m) and 25 subjects in Group 3 (48% male, aged 5.5?±?0.5?m) completed the study. At T0, the weight z-score was similar in Group 1 (−0.74) and 2 (−0.76), with differences compared to Group 3 (−0.17, p?
|Journal||Journal of Pediatric Gastroenterology and Nutrition|
|Publication status||Accepted/In press - Jul 20 2016|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health