Amino Acid Clearance in Cirrhosis: A Predictor of Postoperative Morbidity and Mortality

Richard H. Pearl, George H A Clowes, Silvano Bosari, William V. Mcdermott, James O. Menzoian, Wendy Love, Roger L. Jenkins

Research output: Contribution to journalArticle

Abstract

• The central plasma clearance rate of amino acids (CPCR-AA), the ratio of peripheral amino acid entry rate into blood plasma to arterial amino acid concentration, was measured preoperatively in 149 noninfected cirrhotic patients. In 50 survivors of shunting or general surgical procedures, the mean (±SEM) CPCR-AA was 201±17 mL/m2 min; in 39 subsequent deaths, the mean ratio was 87±14 mL/m2 min. Comparing Child's classification with CPCR-AA reveals the following values: class A (mortality, two of ten patients) survivors, 152±23 mL/m2/min; class A deaths, 96±54 mL m2 min; class C (mortality, 13 of 19 patients) survivors, 214±47 mL/m2/min; class C deaths, 101 ±13 mL m2 min. The preoperative CPCR-AA of 46 patients receiving liver transplants was 91 ± 9 mL/m2/min; 69% of these patients survived. Preoperative CPCR-AA values correlated significantly with rates of hepatic protein synthesis in incubated liver slices obtained by biopsy at operation in 22 patients. Thus, CPCR-AA determination is a true liver function test, valuable in predicting surgical mortality and selecting transplantation or other operations for cirrhotic patients.

Original languageEnglish
Pages (from-to)468-473
Number of pages6
JournalArchives of Surgery
Volume122
Issue number4
DOIs
Publication statusPublished - 1987

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Fibrosis
Morbidity
Amino Acids
Mortality
Survivors
Liver
Liver Function Tests
Transplantation
Transplants
Biopsy
Proteins

ASJC Scopus subject areas

  • Surgery

Cite this

Pearl, R. H., Clowes, G. H. A., Bosari, S., Mcdermott, W. V., Menzoian, J. O., Love, W., & Jenkins, R. L. (1987). Amino Acid Clearance in Cirrhosis: A Predictor of Postoperative Morbidity and Mortality. Archives of Surgery, 122(4), 468-473. https://doi.org/10.1001/archsurg.1987.01400160094015

Amino Acid Clearance in Cirrhosis : A Predictor of Postoperative Morbidity and Mortality. / Pearl, Richard H.; Clowes, George H A; Bosari, Silvano; Mcdermott, William V.; Menzoian, James O.; Love, Wendy; Jenkins, Roger L.

In: Archives of Surgery, Vol. 122, No. 4, 1987, p. 468-473.

Research output: Contribution to journalArticle

Pearl, RH, Clowes, GHA, Bosari, S, Mcdermott, WV, Menzoian, JO, Love, W & Jenkins, RL 1987, 'Amino Acid Clearance in Cirrhosis: A Predictor of Postoperative Morbidity and Mortality', Archives of Surgery, vol. 122, no. 4, pp. 468-473. https://doi.org/10.1001/archsurg.1987.01400160094015
Pearl, Richard H. ; Clowes, George H A ; Bosari, Silvano ; Mcdermott, William V. ; Menzoian, James O. ; Love, Wendy ; Jenkins, Roger L. / Amino Acid Clearance in Cirrhosis : A Predictor of Postoperative Morbidity and Mortality. In: Archives of Surgery. 1987 ; Vol. 122, No. 4. pp. 468-473.
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