Amino acid sequence of k Sci, the Bence Jones protein isolated from a patient with light chain deposition disease

Vittorio Bellotti, Monica Stoppini, Giampaolo Merlini, Maria Carla Zapponi, Maria Laura Meloni, Giovanni Banfi, Giuseppina Ferri

Research output: Contribution to journalArticlepeer-review

Abstract

Light chain Sci was isolated from the urine of a patient affected by light chain deposition disease with an apparent exclusive localization to the kidney. Sci protein is an intact light chain: it consists of 214 amino acid residues and has an Mr of 23.65. Its complete primary structure has been determined by sequence analysis of the corresponding tryptic peptides and by partially sequencing the intact protein. Sequence comparison shows that Sci protein is strictly relatd to the light chains of kIIIa family (88% structural identity) which are usually espressed in autoimmune rheumatoid syndromes. Computer graphics model suggests a perturbation in k Sci three-dimensional structure due to the unusual replacement of residues 53 and 77.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1097
Issue number3
DOIs
Publication statusPublished - Oct 21 1991

Keywords

  • Amino acid sequence
  • Immunoglobulin
  • Light chain deposition disease

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Molecular Medicine

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