Aminoglutethimide as second-line endocrine treatment in metastatic breast cancer

P. Pronzato, A. Ardizzoni, R. Lionetto, P. Conte, R. Rosso

Research output: Contribution to journalArticlepeer-review


Aminoglutethimide, a drug known to block adrenal steroidogensis and peripheral aromatization of androgens to estrogens, has been found effective in the treatment of breast cancer. The drug has been used in our Institute to treat 71 consecutive metastatic breast cancer patients. Of 67 patients evaluable for response, 9 (13.4%) have achieved a partial response, 30 (44.7%) stable disease, and 28 (41.7%) progression of disease. Four patients were taken off the therapy because of drug-related toxicity.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research


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