Aminoglutethimide as second-line endocrine treatment in metastatic breast cancer

P. Pronzato; A. Ardizzoni; R. Lionetto; P. Conte; R. Rosso

Aminoglutethimide as second-line endocrine treatment in metastatic breast cancer

P. Pronzato, A. Ardizzoni, R. Lionetto, P. Conte, R. Rosso

Research output: Contribution to journal › Article › peer-review

Abstract

Aminoglutethimide, a drug known to block adrenal steroidogensis and peripheral aromatization of androgens to estrogens, has been found effective in the treatment of breast cancer. The drug has been used in our Institute to treat 71 consecutive metastatic breast cancer patients. Of 67 patients evaluable for response, 9 (13.4%) have achieved a partial response, 30 (44.7%) stable disease, and 28 (41.7%) progression of disease. Four patients were taken off the therapy because of drug-related toxicity.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	Tumori
Volume	71
Issue number	3
Publication status	Published - 1985

ASJC Scopus subject areas

Cancer Research

Cite this

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abstract = "Aminoglutethimide, a drug known to block adrenal steroidogensis and peripheral aromatization of androgens to estrogens, has been found effective in the treatment of breast cancer. The drug has been used in our Institute to treat 71 consecutive metastatic breast cancer patients. Of 67 patients evaluable for response, 9 (13.4%) have achieved a partial response, 30 (44.7%) stable disease, and 28 (41.7%) progression of disease. Four patients were taken off the therapy because of drug-related toxicity.",

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year = "1985",

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AU - Pronzato, P.

AU - Ardizzoni, A.

AU - Lionetto, R.

AU - Conte, P.

AU - Rosso, R.

PY - 1985

Y1 - 1985

N2 - Aminoglutethimide, a drug known to block adrenal steroidogensis and peripheral aromatization of androgens to estrogens, has been found effective in the treatment of breast cancer. The drug has been used in our Institute to treat 71 consecutive metastatic breast cancer patients. Of 67 patients evaluable for response, 9 (13.4%) have achieved a partial response, 30 (44.7%) stable disease, and 28 (41.7%) progression of disease. Four patients were taken off the therapy because of drug-related toxicity.

AB - Aminoglutethimide, a drug known to block adrenal steroidogensis and peripheral aromatization of androgens to estrogens, has been found effective in the treatment of breast cancer. The drug has been used in our Institute to treat 71 consecutive metastatic breast cancer patients. Of 67 patients evaluable for response, 9 (13.4%) have achieved a partial response, 30 (44.7%) stable disease, and 28 (41.7%) progression of disease. Four patients were taken off the therapy because of drug-related toxicity.

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Aminoglutethimide as second-line endocrine treatment in metastatic breast cancer

Abstract

ASJC Scopus subject areas

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