Abstract
Aurora inhibitors have been extensively studied as potential novel anticancer agents. At least four compounds are now under clinical evaluation. Banyu discloses aminopyridines and -pyrazines acting as selective Aurora-A inhibitors. The claimed compounds demonstrated low nanomolar activity in the biochemical assay and exhibit a 200-fold specificity on Aurora-A versus Aurora-B.
Original language | English |
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Pages (from-to) | 255-261 |
Number of pages | 7 |
Journal | Expert Opinion on Therapeutic Patents |
Volume | 17 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2007 |
Keywords
- Aurora-A
- Aurora-B
- Mitosis
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Pharmacology
- Law