Aminopyrine: metabolism and effects in the rat after administration of inhibitors of hepatic monooxygenases

A. Di Nucci, P. L. Rugarli, B. Ferrini, A. Tarozzi, C. Gregotti, L. Manzo

Research output: Contribution to journalArticle

Abstract

The administration to the rat of the inhibitors of microsomal mixed function oxidases, SKF 52S-A and Oxine-5-sulphonic acid (OSA) caused a significant decrease of the hepatic aminopyrine N-demethylase activity, as well as an increase in the plasma levels and antipyretic activity of orally administered aminopyrine. The plasma concentrations of the aminopyrine metabolite 4-aminoantipyrine were reduced in SKF S2S-A treated animals while they were slightly increased in those pretreated with OSA. These findings suggest that the in vivo changes of aminopyrine disposition and activity brought about by SKF 525-A were the result of an inhibited hepatic drug metabolism, while the effects produced by OSA were due to a more rapid intestinal absorption of aminopyrine.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume4
Issue number3
DOIs
Publication statusPublished - Jul 1979

Fingerprint

Aminopyrine
Mixed Function Oxygenases
Liver
Ampyrone
Aminopyrine N-Demethylase
Proadifen
Antipyretics
Intestinal Absorption
Pharmaceutical Preparations
8-hydroxyquinoline-5-sulfonic acid

Keywords

  • Aminopyrine
  • Drug metabolism
  • Inhibitors of monooxygenases
  • Oxine-5-sulphonic acid
  • SKF 525-A

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Aminopyrine : metabolism and effects in the rat after administration of inhibitors of hepatic monooxygenases. / Di Nucci, A.; Rugarli, P. L.; Ferrini, B.; Tarozzi, A.; Gregotti, C.; Manzo, L.

In: European Journal of Drug Metabolism and Pharmacokinetics, Vol. 4, No. 3, 07.1979, p. 179-183.

Research output: Contribution to journalArticle

Di Nucci, A. ; Rugarli, P. L. ; Ferrini, B. ; Tarozzi, A. ; Gregotti, C. ; Manzo, L. / Aminopyrine : metabolism and effects in the rat after administration of inhibitors of hepatic monooxygenases. In: European Journal of Drug Metabolism and Pharmacokinetics. 1979 ; Vol. 4, No. 3. pp. 179-183.
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